Macroporous methacrylated hyaluronic acid cryogels of high mechanical strength and flow-dependent viscoelasticity
| Autor: | Oguz Okay, Burak Tavsanli |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Fabrication
Aqueous solution Materials science Polymers and Plastics Average diameter Organic Chemistry 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Viscoelasticity 0104 chemical sciences chemistry.chemical_compound Chemical engineering chemistry Mechanical strength Hyaluronic acid Large strain Materials Chemistry 0210 nano-technology Porosity |
| Zdroj: | Carbohydrate Polymers. 229:115458 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2019.115458 |
| Popis: | We present here a new approach for the fabrication of macroporous hyaluronic acid (HA) cryogels with a tunable porous structure, flow-dependent viscoelasticity, and a high mechanical strength. They were synthesized from methacrylated HA in aqueous solutions at −18 °C by free-radical mechanism using in situ prepared poly(N, N-dimethylacrylamide) (PDMAA) as a spacer. Both the porosity and the average diameter of the pores decrease from 99 to 90% and from 150 to 90 μm, respectively, with increasing PDMAA content of the cryogels due to the simultaneous decrease in the amount of ice template during cryogelation. The cryogels also exhibit reversible strain-dependent apparent gel-to-sol transition due to the flowing-out and flowing-in water through the pores. This flow-dependent viscoelasticity is of great interest as it protects HA network from damage under large strain and hence acts as a self-defense mechanism. |
| Databáze: | OpenAIRE |
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