Compartmentalization of growth factor receptor signalling
| Autor: | Siniša Volarević, Daniela Hoeller, Ivan Dikic |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Macromolecular Substances
Growth factor medicine.medical_treatment Intracellular Signaling Peptides and Proteins Cell Biology Signalling compartmentalization growth factor receptors ribosomes signalling and selective translation diseases Biology Endocytosis Cell Compartmentation Cell biology Protein Transport Cell Transformation Neoplastic Growth factor receptor medicine Protein biosynthesis Animals Humans Receptors Growth Factor Signal transduction Growth Substances Receptor Cellular compartment Signal Transduction |
| Zdroj: | Current Opinion in Cell Biology. 17:107-111 |
| ISSN: | 0955-0674 |
| Popis: | Spatial and temporal separation of signal transduction pathways often determines the specificity in cellular responses. Recent advances have improved our understanding of how growth factor signalling is influenced by the formation of molecular complexes (signalosomes) in distinct cellular compartments. There has also been new insight into the mechanisms that determine the signalling competence of these complexes and their role in receptor endocytosis, retrograde trafficking in neurons and restricted protein biosynthesis, and many examples have been found where signalosome deregulation leads to disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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