Caracterização de nanopartículas blenda poliméricas biodegradáveis contendo progesterona
| Autor: | Karine Cristine Kaufmann, Lúcio Cardozo Filho, Odinei Hess Honçalves, Wallace José Maia, Claudia Sayer, Pedro Henrique Hermes de Araújo, Fernanda Vitória Leimann, Maiara Heloisa Biz |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
food.ingredient
Materials science Dispersity Nanoparticle progesterone Lecithin PLLA progesterona lcsh:Agriculture food Pulmonary surfactant Polymer chemistry Fourier transform infrared spectroscopy lcsh:Agriculture (General) chemistry.chemical_classification PHBV General Veterinary interações polímero-droga drug-polymer interactions lcsh:S Polymer Polymeric nanoparticles lcsh:S1-972 Miniemulsion chemistry Chemical engineering PCL Animal Science and Zoology Agronomy and Crop Science |
| Zdroj: | Ciência Rural v.45 n.11 2015 Ciência Rural Universidade Federal de Santa Maria (UFSM) instacron:UFSM Ciência Rural, Vol 45, Iss 11, Pp 2082-2088 (2015) Ciência Rural, Volume: 45, Issue: 11, Pages: 2082-2088, Published: NOV 2015 |
| Popis: | The encapsulation of progesterone in poly (hydroxybutirate-co-hydroxyvalerate) (PHBV), poly (ε-caprolactone) (PCL), poly (L-lactic acid) (PLLA) nanoparticles and PHBV/PCL and PHBV/PLLA blend nanoparticles was investigated in this research. Nanoparticles were produced by miniemulsion/solvent evaporation technique with lecithin as surfactant and were characterized regarding to z-average diameter (Dz) and polydispersity (PDI), progesterone recovery yield and encapsulation efficiency. Possible interactions between progesterone and the polymer matrices were investigated by Fourier Transform Infrared Spectroscopy (FTIR). High recoveries (up to 102.43±1.80% for the PHBV/PLLA blend) and encapsulation efficiencies (up to 99.53±0.04% for PCL) were achieved and the nanoparticles presented narrow size distribution (0.12±0.03 for PLLA). PCL nanoparticles (217.5±2.12nm) presented significant difference with the Dz from all the other formulations (P |
| Databáze: | OpenAIRE |
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