Individualized treatment for allergic rhinitis based on key nasal clinical manifestations combined with histamine and leukotriene D4 levels

Autor: Zhong Wen, Congxiang Shen, Guanxue Li, Huigang Wang, Fang Chen, Xinyu Zhang
Rok vydání: 2020
Předmět:
Cyclopropanes
Male
0301 basic medicine
Disease
Acetates
Sneezing
Gastroenterology
Allergic rhinitis
Leukotriene D4
chemistry.chemical_compound
0302 clinical medicine
Anti-Allergic Agents
Medicine
Precision Medicine
030223 otorhinolaryngology
Leucotrienos
media_common
Tratamento individualizado
Leukotriene
Loratadine
Middle Aged
lcsh:Otorhinolaryngology
lcsh:RF1-547
Treatment efficacy
Treatment Outcome
Histamina
Quinolines
Drug Therapy
Combination
Female
Nasal Obstruction
Histamine
Adult
Drug
Individualized treatment
Leukotrienes
medicine.medical_specialty
Adolescent
Visual analogue scale
media_common.quotation_subject
Sulfides
Young Adult
03 medical and health sciences
Internal medicine
Humans
RNA
Messenger
Receptors
Histamine H1
Aged
Receptors
Leukotriene
Clinical typing
business.industry
Rinite alérgica
Rhinitis
Allergic
Nasal Mucosa
030104 developmental biology
Otorhinolaryngology
chemistry
Tipificação clínica
business
Mometasone Furoate
Zdroj: Brazilian Journal of Otorhinolaryngology v.86 n.1 2020
Brazilian Journal of Otorhinolaryngology
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron:ABORL-CCF
Brazilian Journal of Otorhinolaryngology, Vol 86, Iss 1, Pp 63-73 (2020)
Brazilian Journal of Otorhinolaryngology, Volume: 86, Issue: 1, Pages: 63-73, Published: 30 MAR 2020
ISSN: 1808-8694
DOI: 10.1016/j.bjorl.2018.09.007
Popis: Introduction: The types of allergic rhinitis are roughly classified based on the causative antigens, disease types, predilection time, and symptom severity. Objective: To examine the clinical typing and individualized treatment approach for allergic rhinitis and to determine the optimal treatment method for this disease using various drug combination therapies. Methods: A total of 108 participants with allergic rhinitis were divided into three groups based on symptoms. Subsequently, each group was further categorized into four subgroups based on the medications received. The efficacy of the treatments was evaluated using the visual analog scale VAS scores of the total and individual nasal symptoms, decline index of the symptom score, histamine and leukotriene levels, and mRNA and protein expression levels of histamine 1 and cysteinyl leukotriene 1 receptors. Results: Loratadine + mometasone furoate and loratadine + mometasone furoate + montelukast significantly improved the sneezing symptom and reduced the histamine levels compared with the other combination therapies (p
Databáze: OpenAIRE
Externí odkaz: