Increased T-cell receptor vbeta8+ T cells in bronchoalveolar lavage fluid of subjects with poorly controlled asthma: a potential role for microbial superantigens
| Autor: | Sally E. Wenzel, Pia J. Hauk, Anne E. Trumble, Donald Y.M. Leung, Stanley J. Szefler |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Allergy T cell Receptors Antigen T-Cell alpha-beta Immunology Immunoglobulin Variable Region CD8-Positive T-Lymphocytes Immune system Antigen T-Lymphocyte Subsets Superantigen medicine Immunology and Allergy Humans Asthma Superantigens medicine.diagnostic_test business.industry Middle Aged medicine.disease respiratory tract diseases medicine.anatomical_structure Bronchoalveolar lavage Female business Bronchoalveolar Lavage Fluid Glucocorticoid medicine.drug |
| Zdroj: | The Journal of allergy and clinical immunology. 104(1) |
| ISSN: | 0091-6749 |
| Popis: | Background: T cells are thought to play an important role in the pathogenesis of chronic asthma. The immunologic triggers that contribute to poorly controlled asthma are unknown but may include infectious agents. Superantigens (SAgs), which stimulate T cells expressing selected T-cell receptor (TCR) β-chain variable (Vβ) regions, are known to be an important mechanism by which microbes can contribute to T-cell activation and disease pathogenesis. Objective: We sought to determine the potential role of SAgs in T-cell activation of patients with poorly controlled asthma. Methods: We studied the TCR-Vβ repertoire of bronchoalveolar lavage (BAL) cells and PBMCs from 9 subjects with poorly controlled asthma (FEV 1 80%), and 8 normal control subjects with the use of anti-TCR-Vβ–specific mAbs and flow cytometry. Results: Subjects with poorly controlled asthma had a significantly higher expression of Vβ8 + T cells in BAL fluid than subjects with well-controlled asthma and normal control subjects ( P P + BAL T cells were present in CD4 + ( P + ( P Conclusion: These results indicate that SAgs are a potential trigger of T-cell activation in poorly controlled asthma. (J Allergy Clin Immunol 1999;103:37-45.) |
| Databáze: | OpenAIRE |
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