Furosemide in patients with heart failure: shift in dose-response curves
| Autor: | Polavat Chennavasin, D. Craig Brater, Ruth Seiwell |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Sodium chemistry.chemical_element Excretion Furosemide Internal medicine Medicine Humans Pharmacology (medical) In patient Aged Pharmacology Heart Failure Dose-Response Relationship Drug business.industry Middle Aged medicine.disease Dose–response relationship Endocrinology chemistry Heart failure Time course Cardiology Female Kidney Diseases business medicine.drug |
| Zdroj: | Clinical pharmacology and therapeutics. 28(2) |
| ISSN: | 0009-9236 |
| Popis: | We studied 10 patients with congestive heart failure to assess the dynamics of their response to 40 mg of furosemide. Patients excreted less sodium than normal controls: 142 +/- 36 and 245 +/- 16 mEq/4 hr (p < 0.05). Patients delivered the same amount of furosemide into the urine--14.9 +/- 2.0 and 18.7 +/- 2.1 mg/4 hr (p < 0.20)--but the time course of delivery differed. Normal subjects had a sigmoid-shaped curve when furosemide excretion rate was related to response. All patients but one had shifts in this curve and for a number of patients the configuration differed substantially from a sigmoid curve. |
| Databáze: | OpenAIRE |
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