Self‐Report versus Clinician Examination in Early Parkinson's Disease

Autor: Sheida Zolfaghari, Alessandra E. Thomann, Natalia Lewandowski, Dylan Trundell, Florian Lipsmeier, Gennaro Pagano, Kirsten I. Taylor, Ronald B. Postuma
Rok vydání: 2021
Předmět:
Zdroj: Movement Disorders. 37:585-597
ISSN: 1531-8257
0885-3185
Popis: Evaluating the discrepancies between patient-reported measures and clinician examination has implications for formulating individual treatment regimens.This study investigated the association between health outcomes and level of self-reported motor-related function impairment relative to clinician-examined motor signs.Recently diagnosed PD patients were evaluated using the Parkinson's Progression Marker Initiative (PPMI, N = 420) and the PASADENA phase II clinical trial (N = 316). We calculated the average normalized difference between each participant's part II and III MDS-UPDRS (Movement Disorder Society Unified Parkinson's Disease Rating Scale) scores. Individuals with score differences25th or75th percentiles were labeled as low- and high-self-reporters, respectively (those between ranges were labeled intermediate-self-reporters). We compared a wide range of clinical/biomarker readouts among these three groups, using Kruskal-Wallis nonparametric and Pearson's χIn both cohorts, high-self-reporters reported the largest impairment/symptom experience for most motor and nonmotor patient-reported variables. By contrast, these high-self-reporters were similar to or less impaired on clinician-examined and biomarker measures. Patient-reported nonmotor symptoms on MDS-UPDRS part IB showed the strongest positive correlation with self-reported motor-related impairment (PPMI rSelf-reported motor-related impairments reflect not only motor signs/symptoms but also other self-reported nonmotor measures. This may indicate (1) a direct impact of nonmotor symptoms on motor-related functioning and/or (2) the existence of general response tendencies in how patients self-rate symptoms. Our findings suggest further investigation into the suitability of MDS-UPDRS II to assess motor-related impairments. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Databáze: OpenAIRE
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