| Autor: |
Rosanne Boudreau, Mathew Thomas, Axel Ekman, James Evans, Gerry McDermott, Jian-Hua Chen, Emma Patello, Hong-fei Wang, William B. Chrisler, Chuck R. Smallwood |
| Rok vydání: |
2018 |
| Předmět: |
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| DOI: |
10.1101/249052 |
| Popis: |
Lipid droplet biogenesis, accumulation and secretion is an important field of research spanning biofuel feedstock production in algae and yeast to plant-microbe symbiosis or human metabolic disorders and other diseases. Here we evaluate the critical elements that influence lipid accumulation in the highly simplified and smallest known eukaryote Ostreococcus tauri and identify several conditions that satisfy its classification as an oleaginous green alga. In addition, these experiments revealed the release of excess lipids in pea-pod like structures where many dense lipid droplets are clustered in a linear fashion surrounded by an enveloping membrane which contrasts with known mechanisms from other eukaryotes. These results highlight the potential for Ostreococcus tauri to probe the evolution of lipid droplet dynamics as an emerging model organism with a compacted eukaryotic genome and also to impact lipid feedstock bioproduction applications either directly or using synthetic biology.One Sentence SummaryThe smallest known eukaryote Ostreococcus tauri is oleaginous and sheds lipid droplets as pea-pod like membrane enclosed clusters. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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