Patterns of desmin expression in idiopathic dilated cardiomyopathy are related to the desmin mRNA and ubiquitin expression

Autor:	Katarzyna Gil, Andrzej Ziemba, Agnieszka Pawlak, Robert J. Gil, Leszek Kaczmarek, Emilia Rejmak-Kozicka
Rok vydání:	2018
Předmět:	Cardiomyopathy Dilated Male 030213 general clinical medicine Pathology medicine.medical_specialty macromolecular substances 030204 cardiovascular system & hematology General Biochemistry Genetics and Molecular Biology Desmin 03 medical and health sciences 0302 clinical medicine Ubiquitin Idiopathic dilated cardiomyopathy Natriuretic Peptide Brain medicine Humans Myocytes Cardiac RNA Messenger Messenger RNA Ejection fraction biology business.industry Dilated cardiomyopathy General Medicine Middle Aged musculoskeletal system medicine.disease Fibrosis Peptide Fragments Proteasome Gene Expression Regulation Heart failure biology.protein Female business
Zdroj:	Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 67(1)
ISSN:	1708-8267
Popis:	Desmin expression depends on desmin messenger RNA (mRNA) and ubiquitin proteasome system. This process is poorly understood in dilated cardiomyopathy. The aim of the study was to investigate whether changes of desmin mRNA and ubiquitin expression correlate with types of desmin expression in cardiomyocytes. Endomyocardial biopsy was performed in 60 patients (85% men, mean age 46±14 years) with heart failure (HF; left ventricular ejection fraction
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08507838a7a0ec5ceb3408d0c1b7fba https://pubmed.ncbi.nlm.nih.gov/30097466 Zobrazit plný text záznamu