Significance of increasing adhesion of cord blood hematopoietic cells and a new method: platelet microparticles
| Autor: | Shaoqin Wu, Can Liao, Zun-Peng Xu, Jing-Song Chen, Bin Liu, Shao-Ling Gu |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Blood Platelets
Male Receptors CXCR4 Adolescent CD34 Antigens CD34 CXCR4 medicine Cell Adhesion Humans L-Selectin Child business.industry Cell adhesion molecule Graft Survival Infant Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Fetal Blood Hematopoietic Stem Cells Fibronectins Transplantation Haematopoiesis medicine.anatomical_structure Cord blood Child Preschool Immunology Cancer research Female Bone marrow Cord Blood Stem Cell Transplantation Endothelium Vascular business Homing (hematopoietic) |
| Zdroj: | American journal of hematology. 74(3) |
| ISSN: | 0361-8609 |
| Popis: | Hematopoietic recovery after transplantation with cord blood (CB) is slower than with bone marrow (BM) and mobilized peripheral blood. Adhesion molecules (AMs) on hematopoietic cells are involved in hematopoietic cells' homing. It may be possible to enhance CB CD34+ cells engraftment by increasing their expressions of AM. Twenty-three patients with childhood acute leukemia treated with unrelated CBT were studied. It was found that the time to neutrophil recovery correlated with CXCR4 and the time to platelet recovery correlated with both CD62L and CXCR4. Platelet microparticles (PMPs) carry some AMs such as aIIb b (CD41), P-selectin (CD62P), and CXCR4, CD34+ cells express platelet-binding antigens (CD162 and CD11b). It was found that AMs were increased dramatically on CD34+ cells surface in the presence of PMPs, and CD34+ cells covered with PMPs adhered better to human umbilical vein endothelial cells and fibronectin. These findings suggested that PMPs could increase adhesion of donor's cells to host BM in CBT. Am. J. Hematol. 74:216–217, 2003. © 2003 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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