Cost analysis of smear microscopy and the Xpert assay for tuberculosis diagnosis: average turnaround time
Autor: | Lucas Benício Dos Santos, Maria Claudia Vater, Silvana Spíndola de Miranda, Caroline Gontijo Gonçalves Manso, Afrânio Lineu Kritski, Lida Jouca de Assis Figueredo, Isabela Neves de Almeida, Cristiane Aparecida Menezes de Pádua, Valéria Martins Soares, Suely Alves, Wânia da Silva Carvalho |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Tuberculosis RC955-962 030106 microbiology 030231 tropical medicine Turnaround time Sensitivity and Specificity Smear microscopy Molecular diagnostic Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Tuberculosis diagnosis Arctic medicine. Tropical medicine parasitic diseases medicine Major Article Cost analysis Humans Health system Pathology Molecular Tuberculosis Pulmonary health care economics and organizations Microscopy biology business.industry Pulmonary tuberculosis biology.organism_classification University hospital medicine.disease Patient diagnosis Infectious Diseases Emergency medicine Costs and Cost Analysis Parasitology Biological Assay business |
Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical, Volume: 53, Article number: e20200314, Published: 25 SEP 2020 Revista da Sociedade Brasileira de Medicina Tropical v.53 2020 Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020) |
Popis: | INTRODUCTION: Rapid and accurate tuberculosis detection is critical for improving patient diagnosis and decreasing tuberculosis transmission. Molecular assays can significantly increase laboratory costs; therefore, the average time and economic impact should be evaluated before implementing a new technology. The aim of this study was to evaluate the cost and average turnaround time of smear microscopy and Xpert assay at a university hospital. METHODS: The turnaround time and cost of the laboratory diagnosis of tuberculosis were calculated based on the mean cost and activity based costing (ABC). RESULTS: The average turnaround time for smear microscopy was 16.6 hours while that for Xpert was 24.1 hours. The Xpert had a mean cost of USD 17.37 with an ABC of USD 10.86, while smear microscopy had a mean cost of USD 13.31 with an ABC of USD 6.01. The sensitivity of smear microscopy was 42.9% and its specificity was 99.1%, while the Xpert assay had a sensitivity of 100% and a specificity of 96.7%. CONCLUSIONS: The Xpert assay has high accuracy; however, the turnaround time and cost of smear microscopy were lower than those of Xpert. |
Databáze: | OpenAIRE |
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