UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death

Autor:	Miho Koizumi, Hikaru Eto, Mai Saeki, Masahide Seki, Tsuyoshi Fukushima, Shoichiro Mukai, Hisamitsu Ide, Yasuyuki Sera, Masayuki Iwasaki, Yutaka Suzuki, Atsushi Tohei, Yusuke Kishi, Hiroaki Honda
Rok vydání:	2022
Předmět:	Male Histone Demethylases Neurogenesis Stem Cells Biochemistry Fetal Development Histones Mice Neural Stem Cells Genetics Animals Female Molecular Biology Biotechnology Hydrocephalus
Zdroj:	FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(12)
ISSN:	1530-6860
Popis:	Recent studies have demonstrated that epigenetic modifications are deeply involved in neurogenesis; however, the precise mechanisms remain largely unknown. To determine the role of UTX (also known as KDM6A), a demethylase of histone H3K27, in neural development, we generated Utx-deficient mice in neural stem/progenitor cells (NSPCs). Since Utx is an X chromosome-specific gene, the genotypes are sex-dependent; female mice lose both Utx alleles (Utx
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0803febfe3c3b716b985f1df18cc66d https://pubmed.ncbi.nlm.nih.gov/36607616 Zobrazit plný text záznamu Plný text