Prospective randomized study of efficacy of 1-day versus 3-day antibiotic prophylaxis for preventing surgical site infection after coronary artery bypass graft
| Autor: | Fang Yue Lin, Yee-Chun Chen, Sung-Ching Pan, Shan-Chwen Chang, Ron-Bin Hsu, Jiun-Ling Wang, Mei Hsin Lin, Fei Lin Lin Wu |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Cefazolin Logistic regression law.invention Randomized controlled trial law Medicine Humans Surgical Wound Infection Antibiotic prophylaxis Coronary Artery Bypass Aged Medicine(all) lcsh:R5-920 business.industry General Medicine Odds ratio Antibiotic Prophylaxis Middle Aged Confidence interval Surgery Anti-Bacterial Agents medicine.anatomical_structure Female business lcsh:Medicine (General) Surgical site infection Artery medicine.drug |
| Zdroj: | Journal of the Formosan Medical Association, Vol 110, Iss 10, Pp 619-626 (2011) |
| ISSN: | 0929-6646 |
| DOI: | 10.1016/j.jfma.2011.08.003 |
| Popis: | Background/Purpose Despite general recommendation of short-course antibiotic prophylaxis, prolonged antibiotic use is still commonly reported in clinical settings. This study compared the efficacy of 1-day versus 3-day antibiotic prophylaxis in preventing surgical site infection (SSI) in patients undergoing coronary artery bypass graft (CABG). Methods This prospective, randomized control study was performed in a tertiary-care medical center from June 2002 to April 2004. Patients underwent non-emergency CABG and were randomized into two groups receiving either 1 day or 3 days cefazolin prophylaxis. The SSI rates were compared between the two groups. Results During the study period, 231 patients were enrolled, 120 in the 1-day group and 111 in the 3-day group. Twenty-two episodes of SSI were observed within 1 month after operation: 13 (10.8%) in the 1-day group and nine (8.1%) in the 3-day group (odds ratio: 1.37; 95% confidence interval: 0.56–3.33; p = 0.48). By logistic regression analysis, 1-day prophylaxis with cefazolin was not associated with higher risk of SSI (adjusted odds ratio: 0.91; 95% confidence interval: 0.32–2.56; p = 0.85). Conclusion Antibiotic prophylaxis for 1 day in CABG surgery was associated with similar rates of postoperative infection compared with antibiotic prophylaxis of 3 days. |
| Databáze: | OpenAIRE |
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