1-Methyl-4-(2′-methylphenyl)-1,2,3,6-tetrahydropyridine (2′-CH3-MPTP) is a more potent dopaminergic neurotoxin than MPTP in mice
| Autor: | Roger C. Duvoisin, Stephen K. Youngster, Arthur Hess, M V Kindt, Patricia K. Sonsalla, Richard E. Heikkila |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Pyridines Ratón animal diseases Substantia nigra Pharmacology Receptors Dopamine Mice chemistry.chemical_compound Dopamine 2'-CH3-MPTP medicine Animals Neurotoxin cardiovascular diseases MPTP Dopaminergic Brain nervous system diseases Mice Inbred C57BL Substantia Nigra nervous system chemistry 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Toxicity cardiovascular system Neuroscience medicine.drug |
| Zdroj: | European Journal of Pharmacology. 122:283-287 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(86)90115-9 |
| Popis: | The administration to mice of 1-methyl-4-(2′-methylphenyl)-1,2,3,6-tetrahydropyridine (2′-CH3-MPTP), a substituted analog of the dopaminergic neurotoxin MPTP caused even more dopaminergic toxicity than MPTP itself. Under conditions in which MPTP was relatively ineffective (i.e. two injections per day of 0.113 mmol/kg at an interval of 6 h for one or two days), 2′-CH3-MPTP caused a very large decrement in the neostriatal content of dopamine and its metabolites and a corresponding decrement in the capacity of a neostriatal synaptosomal preparation to take up [3H]dopamine. Moreover, 2′-CH3-MPTP administration (as few as four injections) caused a virtually complete loss of nerve cells in the zona compacta of the substantia nigra. This compound, like MPTP, may prove to be a valuable research tool. |
| Databáze: | OpenAIRE |
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