Memory and survival after microbeam radiation therapy
| Autor: | Hans Blattmann, Tomasz Wysokinsky, Elke Bräuer-Krisch, Robert Griebel, Evan Frangou, Elisabeth Schültke, Joanna Minczewska, K Ataelmannan, Jeffrey C. Crosbie, Bernhard H.J. Juurlink, Jean A. Laissue, L. Dean Chapman, Daryl R. Fourney, Hadi Taherian, Alberto Bravin |
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| Přispěvatelé: | Schultke, E, Juurlink, B, Ataelmannan, K, Laissue, J, Blattmann, H, Brauer-Krisch, E, Bravin, A, Minczewska, J, Crosbie, J, Taherian, H, Frangou, E, Wysokinsky, T, Chapman, L, Griebel, R, Fourney, D |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
MRT medicine.medical_treatment FIS/07 - FISICA APPLICATA (A BENI CULTURALI AMBIENTALI BIOLOGIA E MEDICINA) Radiotherapy High-Energy memory Microbeam radiation therapy Entrance skin dose Small animal medicine Adjuvant therapy Animals Radiology Nuclear Medicine and imaging Rats Wistar Radiation Injuries Adverse effect Memory Disorders Brain Neoplasms business.industry Dose-Response Relationship Radiation Radiotherapy Dosage Glioma General Medicine Survival Analysis Rats Survival Rate Glutamine Radiation therapy Malignant brain tumour x-ray microbeam Treatment Outcome Immunology business Nuclear medicine |
| Popis: | Background: Disturbances of memory function are frequently observed in patients with malignant brain tumours and as adverse effects after radiotherapy to the brain. Experiments in small animal models of malignant brain tumour using synchrotron-based microbeam radiation therapy (MRT) have shown a promising prolongation of survival times. Materials and methods: Two animal models of malignant brain tumour were used to study survival and memory development after MRT. Thirteen days after implantation of tumour cells, animals were submitted to MRT either with or without adjuvant therapy (buthionine-SR-sulfoximine = BSO or glutamine). We used two orthogonal 1-cm wide arrays of 50 microplanar quasiparallel microbeams of 25m width and a center-to-center distance of about 200m, created by a multislit collimator, with a skin entrance dose of 350 Gy for each direction. Object recognition tests were performed at day 13 after tumour cell implantation and in monthly intervals up to 1 year after tumour cell implantation. Results: In both animal models, MRT with and without adjuvant therapy significantly increased survival times. BSO had detrimental effects on memory function early after therapy, while administration of glutamine resulted in improved memory. © 2008 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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