Differentiating tic electrophysiology from voluntary movement in the human thalamocortical circuit
| Autor: | Stephanie Cernera, Jackson N. Cagle, Michael S. Okun, Rene Molina, Enrico Opri, Kelly D. Foote, Aysegul Gunduz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Tics Movement Thalamus Neuroimaging Tourette syndrome Article Stereotaxic Techniques 03 medical and health sciences Electrocardiography 0302 clinical medicine Physical medicine and rehabilitation Neurodevelopmental disorder Cortex (anatomy) medicine Humans 030304 developmental biology 0303 health sciences business.industry Intralaminar Thalamic Nuclei Motor Cortex Middle Aged medicine.disease Magnetic Resonance Imaging Neuromodulation (medicine) Electrodes Implanted Electrophysiological Phenomena Functional imaging Psychiatry and Mental health Electrophysiology medicine.anatomical_structure Surgery Female Neurology (clinical) business Tomography X-Ray Computed 030217 neurology & neurosurgery Tourette Syndrome |
| Zdroj: | J Neurol Neurosurg Psychiatry |
| ISSN: | 1468-330X |
| Popis: | ObjectivesTourette syndrome is a neurodevelopmental disorder commonly associated with involuntary movements, or tics. We currently lack an ideal animal model for Tourette syndrome. In humans, clinical manifestation of tics cannot be captured via functional imaging due to motion artefacts and limited temporal resolution, and electrophysiological studies have been limited to the intraoperative environment. The goal of this study was to identify electrophysiological signals in the centromedian (CM) thalamic nucleus and primary motor (M1) cortex that differentiate tics from voluntary movements.MethodsThe data were collected as part of a larger National Institutes of Health-sponsored clinical trial. Four participants (two males, two females) underwent monthly clinical visits for collection of physiology for a total of 6 months. Participants were implanted with bilateral CM thalamic macroelectrodes and M1 subdural electrodes that were connected to two neurostimulators, both with sensing capabilities. MRI scans were performed preoperatively and CT scans postoperatively for localisation of electrodes. Electrophysiological recordings were collected at each visit from both the cortical and subcortical implants.ResultsRecordings collected from the CM thalamic nucleus revealed a low-frequency power (3–10 Hz) increase that was time-locked to the onset of involuntary tics but was not present during voluntary movements. Cortical recordings revealed beta power decrease in M1 that was present during tics and voluntary movements.ConclusionWe conclude that a human physiological signal was detected from the CM thalamus that differentiated tic from voluntary movement, and this physiological feature could potentially guide the development of neuromodulation therapies for Tourette syndrome that could use a closed-loop-based approach. |
| Databáze: | OpenAIRE |
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