A Stepwise Approach Using Metastatic Lymph Node Ratio-Combined Thyroglobulin for Customization of [18F]FDG-PET/CT Indication to Detect Persistent Disease in Patients with Papillary Thyroid Cancer
| Autor: | Young Jae Ryu, Seong Young Kwon, Su Woong Yoo, Ayoung Pyo, Subin Jeon, Hee-Seung Bom, Jung-Joon Min, Hong Hua Piao, Dong-Yeon Kim |
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| Rok vydání: | 2021 |
| Předmět: |
[18F]FDG PET/CT
Medicine (General) medicine.medical_treatment Clinical Biochemistry persistent disease thyroglobulin Article 030218 nuclear medicine & medical imaging Papillary thyroid cancer 03 medical and health sciences R5-920 0302 clinical medicine Medicine papillary thyroid cancer In patient Lymph node business.industry Retrospective cohort study medicine.disease Persistent Disease medicine.anatomical_structure lymph node ratio 030220 oncology & carcinogenesis Fdg pet ct Thyroglobulin Lymph business Nuclear medicine |
| Zdroj: | Diagnostics Diagnostics, Vol 11, Iss 836, p 836 (2021) Volume 11 Issue 5 |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics11050836 |
| Popis: | We investigated whether an indication for [18F]FDG-PET/CT to detect FDG-avid persistent disease (PD) could be identified precisely using the extent of metastatic lymph nodes (MLNs) and serum thyroglobulin (Tg) in papillary thyroid cancer (PTC) patients. This retrospective study included 429 PTC patients who underwent surgery and radioactive iodine (RAI) therapy. [18F]FDG-PET/CT and serum Tg were evaluated just before RAI therapy. The MLN ratio (LNR) was defined as the ratio of the number of MLNs to the number of removed LNs. To derive the LNR-combined criteria, different Tg cut-off values for identifying the PET/CT-indicated group for PD detection were applied individually to subgroups initially classified based on LNR cut-off values. The cut-off values for serum Tg, the number of MLNs, and LNR for a PET/CT indication were 6.0 ng/mL, 5, and 0.51, respectively. Compared to a single parameter (serum Tg, total number of MLNs, and LNR), the LNR-combined criteria showed significantly superior diagnostic performance in detecting FDG-avid PD (p < 0.001). The diagnostic performance of PET/CT in detecting FDG-avid PD was significantly improved when the PET/CT-indicated group was identified through the LNR-combined criteria in a stepwise manner this can contribute to a customized PET/CT indication in PTC patients. |
| Databáze: | OpenAIRE |
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