The expression and activity of renal nitric oxide synthase and circulating nitric oxide in polycystic kidney disease rats
| Autor: | Dan Wang, Svend Strandgaard, Thomas Horn, Otto Brændstrup, Svend Larsen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Endothelium Nitric Oxide Synthase Type III Nitric Oxide Synthase Type II Nitric Oxide Synthase Type I Endothelial NOS Kidney Nitric Oxide Rats Mutant Strains Pathology and Forensic Medicine Nitric oxide Rats Sprague-Dawley chemistry.chemical_compound Enos Internal medicine medicine Polycystic kidney disease Immunology and Allergy Animals Urea biology Chemistry General Medicine medicine.disease biology.organism_classification Polycystic Kidney Autosomal Dominant Immunohistochemistry Rats Nitric oxide synthase medicine.anatomical_structure Endocrinology biology.protein Female Nitric Oxide Synthase |
| Zdroj: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 112(6) |
| ISSN: | 0903-4641 |
| Popis: | Nitric oxide (NO) influences tubular fluid and electrolyte transport, and hence possibly also fluid accumulation in renal cysts. The expression and activity of intrarenal constitutive NO synthase (cNOS) [neuronal NOS, nNOS and endothelial NOS, eNOS] and inducible NOS (iNOS) and plasma nitrite/nitrate (PNOx) concentration were assessed in homozygous Han:SPRD polycystic kidney disease (PKD) rats (cy/cy), heterozygous Han:SPRD PKD rats (cy/+), homozygous normal Han:SPRD littermates (+/+) and Sprague Dawley rats (sd). The results showed: 1) nNOS expression was decreased in proximal tubules and thick ascending limbs of the loop of Henle in cy/cy and cy/+ rats compared to +/+ and sd rats (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|