Attenuation of the Neurotoxic Effect of Aβ Amyloid Peptide by Apolipoprotein E
| Autor: | J. S. Whitson, J. D. Morrisett, Warren J. Strittmatter, Stanley H. Appel, T. Yamaki, Martha P. Mims |
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| Rok vydání: | 1994 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty Amyloid Cell Survival Neurotoxins Biophysics Peptide In Vitro Techniques Biology Hippocampus Biochemistry Rats Sprague-Dawley Apolipoproteins E Internal medicine medicine Animals Avidity Senile plaques Molecular Biology chemistry.chemical_classification Amyloid beta-Peptides Neurotoxicity P3 peptide Cell Biology medicine.disease Rats Endocrinology chemistry Immunology lipids (amino acids peptides and proteins) Alzheimer's disease Protein Binding |
| Zdroj: | Biochemical and Biophysical Research Communications. 199:163-170 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1994.1209 |
| Popis: | Alzheimer's disease patients have increased frequency of apolipoprotein E allele c4, suggesting apoE4 is a risk factor determining disease. ApoE binds A beta amyloid peptide with great avidity in vitro and in the neuritic plaque. Potentially, binding of A beta to apolipoprotein E could increase A beta neurotoxicity. However, in hippocampal cultures, 0.1 microM apolipoprotein E eliminated the neurotoxicity of 10 microM A beta. Neuronal rescue was dose-dependent and occurred even after 48 hours exposure to A beta, but was overwhelmed by excess A beta. Thus, interaction between these proteins does not directly increase A beta neurotoxicity, and the role of ApoE in Alzheimer's disease remains to be elucidated. |
| Databáze: | OpenAIRE |
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