The Synthesis of Cinchonine Tiglat Ester Compound and Cytotoxic Test Against MCF-7 Breast Cancer Cell
| Autor: | Muhammad Hanafi, Ahmad Khanifudin, Sylvia Rizky Prima, Gian Primahana, Puspa Dewi Lotulung |
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| Přispěvatelé: | Ahmad Khanifudin, UNTAG, Gian Primahana2, LIPI, Sylvia Rizky Prima, UNTAG, Puspa D. Lotulung, LIPI |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry); Vol 19, No 2 (2017); 54-61 |
| ISSN: | 0853-2788 2527-7669 |
| Popis: | Cinchonine is a type of cinchona alkaloid compound commonly found and/or isolated from Cinchona sp. plant. It is commonly used to treat malaria, and can potentially be used against cancer cells. In this particular study, cinchonine ester derivatives were extracted through esterification processs. Synthesized esther is aimed to gain higher lipophilicity of cinchonine so that makes it easier to pass through cell membrane. Esterification was done using DCC activator as well as DMAP catalyst with tiglic acid used to create cinchonine tiglat. Subsequent cinchonine tiglat was obtained in the form of oil with 25,28% yield. The compound obtained from the synthesis was the analyzed using LC-ESI-MS and 1H-NMR spectroscopy instrumentation. Results show that the target compound has been successfully synthesized. Its cytotoxic ability against MCF-7 breast cancer cells was tested using the Alamar Blue method. Results concluded that cinchonine tiglat ester compound has a viable cytotoxic activity with IC50 value of 1.22 ppm. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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