High frequency of HLA-DR5 in Greek patients with haemophilia A and haemophilia B
| Autor: | Chr. Mitsouli, M. Varla, T. Mandalaki, C. Papasteriades, J. Economidou, K. Marcacis, A. Roumeliotou, K. Louisou, G. Papaevangelou |
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| Rok vydání: | 2008 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty Immunology Haemophilia A Human leukocyte antigen Antibodies Viral Hemophilia A Haemophilia Deltaretrovirus HLA-DR5 Antigen Hemophilia B Biochemistry Gastroenterology Gene Frequency Antigen hemic and lymphatic diseases Internal medicine Genetics Coagulopathy medicine Humans Immunology and Allergy Haemophilia B Allele frequency Acquired Immunodeficiency Syndrome Greece biology business.industry Histocompatibility Antigens Class II General Medicine medicine.disease biology.protein Antibody business |
| Zdroj: | Tissue Antigens. 28:84-87 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1986.tb00465.x |
| Popis: | Sixty unrelated Greek patients with haemophilia (46 with haemophilia A and 14 with haemophilia B) were typed for HLA-A, B and DR antigens. A highly significant increase in the frequency of HLA-DR5 was observed in both groups of patients (58.6% vs 30.0%, chi 2 = 10.47, pc less than 0.03, RR = 3.31 for haemophilia A and 78.5% vs 30.0%, chi 2 = 12.32, pc less than 0.007, RR = 8.5 for haemophilia B). An increased frequency of HLA-B13 was also observed in patients with haemophilia A (15.2% vs 5.7%, chi 2 = 5.74, pc less than 0.4, RR = 2.9). Thirty of the 60 patients (50.0%) were positive for LAV/HTLVIII antibodies. HLA-DR5 was equally distributed in patients with and without these antibodies (63.3% and 63.3%, respectively). The presence of DR5 did not correlate with the severity of haemophilia A or B. These results may suggest an influence of gene(s) on chromosome 6 in haemophilia A and haemophilia B and no effect of HLA antigens in the susceptibility to LAV/ HTLVIII infection among haemophiliac patients. |
| Databáze: | OpenAIRE |
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