Genetic architecture of transmission stage production and virulence in schistosome parasites

Autor:	Tim J. Anderson, Vinay Menon, Frédéric D. Chevalier, Marina McDew-White, Grace-Ann Arya, Winka Le Clec’h
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Microbiology (medical) Multifactorial Inheritance Quantitative Trait Loci Immunology Virulence Snail Infectious and parasitic diseases RC109-216 Biology Quantitative trait locus Microbiology Host-Parasite Interactions 03 medical and health sciences Genetic linkage biology.animal parasitic diseases Animals Biomphalaria glabrata Cercaria life history traits 030304 developmental biology Genetics 0303 health sciences genetic crosses Biomphalaria 030306 microbiology fungi transmission Schistosoma mansoni biology.organism_classification Phenotype Genetic architecture virulence Infectious Diseases quantitative trait loci (qtl) Parasitology schistosoma parasite biomphalaria snail host Research Article Research Paper
Zdroj:	Virulence, Vol 12, Iss 1, Pp 1508-1526 (2021) Virulence article-version (VoR) Version of Record
ISSN:	2150-5608 2150-5594
Popis:	Both theory and experimental data from pathogens suggest that the production of transmission stages should be strongly associated with virulence, but the genetic bases of parasite transmission/virulence traits are poorly understood. The blood fluke Schistosoma mansoni shows extensive variation in numbers of cercariae larvae shed and in their virulence to infected snail hosts, consistent with expected trade-offs between parasite transmission and virulence. We crossed schistosomes from two populations that differ 8-fold in cercarial shedding and in their virulence to Biomphalaria glabrata snail hosts, and determined four-week cercarial shedding profiles in F0 parents, F1 parents and 376 F2 progeny from two independent crosses in inbred snails. Sequencing and linkage analysis revealed that cercarial production is polygenic and controlled by five QTLs (i.e. Quantitative Trait Loci). These QTLs act additively, explaining 28.56% of the phenotypic variation. These results demonstrate that the genetic architecture of key traits relevant to schistosome ecology can be dissected using classical linkage mapping approaches.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07395f6f338838ca365bd64f26d2420 https://doaj.org/article/450aff1361ae4c1bb4c6a2fada95e3de Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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