Ticlopidine-, Clopidogrel-, and Prasugrel-Associated Thrombotic Thrombocytopenic Purpura: A 20-Year Review from the Southern Network on Adverse Reactions (SONAR)
| Autor: | Sony Jacob, Ravindra Sarode, Sara E. Barnato, John F. Cursio, Ivy Weiss, Hao Chen, Patricia M. Carey, Constance Danielson, Fei Chen, Dilip K. Pandey, John M. Armstrong, Masanori Matsumoto, Hau C. Kwaan, Joseph E. Kiss, Thomas J. Raife, Jeffrey L. Winters, Nicholas Bandarenko, William F. Clark, Gail Rock, Thomas L. Ortel, Charles L. Bennett, Yoshihiro Fujimura, Dennis W. Raisch, June M. McKoy, Zaina P. Qureshi, Brianne L. Dunn, X. Long Zheng |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Ticlopidine Prasugrel Thienopyridines Thrombotic thrombocytopenic purpura Thiophenes Pharmacology Gastroenterology Piperazines Article hemic and lymphatic diseases Internal medicine medicine Humans heterocyclic compounds Adverse effect neoplasms Prasugrel Hydrochloride Purpura Thrombotic Thrombocytopenic business.industry Hematology respiratory system medicine.disease Clopidogrel Platelet aggregation inhibitor Cardiology and Cardiovascular Medicine business therapeutics Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Seminars in Thrombosis and Hemostasis. 38:845-853 |
| ISSN: | 1098-9064 0094-6176 |
| DOI: | 10.1055/s-0032-1328894 |
| Popis: | Thienopyridine-derivatives (ticlopidine, clopidogrel, and prasugrel) are the primary antiplatelet agents. Thrombotic thrombocytopenic purpura (TTP) is a rare drug-associated syndrome, with the thienopyridines being the most common drugs implicated in this syndrome. We reviewed 20 years of information on clinical, epidemiologic, and laboratory findings for thienopyridine-associated TTP. Four, 11, and 11 cases of thienopyridine-associated TTP were reported in the first year of marketing of ticlopidine (1989), clopidogrel (1998), and prasugrel (2010), respectively. As of 2011, the FDA received reports of 97 ticlopidine-, 197 clopidogrel-, and 14 prasugrel-associated TTP cases. Severe deficiency of ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) was present in 80% and antibodies to 100% of these TTP patients on ticlopidine, 0% of the patients with clopidogrel-associated TTP (p < 0.05), and an unknown percentage of patients with prasugrel-associated TTP. TTP is associated with use of each of the three thienopyridines, although the mechanistic pathways may differ. |
| Databáze: | OpenAIRE |
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