Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes
| Autor: | J D Santamaria, A J Hall, R J Stawell, P M Hoffman, Penny McKelvie |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Radiation retinopathy Eye disease Vision Disorders Recurrence hemic and lymphatic diseases medicine Humans T-cell lymphoma Radiation Injuries Survival analysis Aged Retrospective Studies Radiotherapy business.industry Eye Neoplasms Lymphoma Non-Hodgkin Retrospective cohort study Middle Aged Prognosis medicine.disease Survival Analysis eye diseases Lymphoma Surgery Ophthalmology Treatment Outcome Female Intraocular lymphoma Complication business |
| Zdroj: | Eye. 17:513-521 |
| ISSN: | 1476-5454 0950-222X |
| DOI: | 10.1038/sj.eye.6700378 |
| Popis: | Aims To assess the clinical features, pathology, mortality (systemic outcome) and ocular complications (visual outcome) of a cohort of patients treated for intraocular lymphoma. Methods Retrospective case analysis of medical records and review of pathology of a consecutive series of patients presenting with intraocular lymphoma in Melbourne over 11 years between 1990 and 2000. Categorical factors influencing survival were examined by the Kaplan–Meier estimator and groups compared with the log rank test. Results A total of 14 patients were included. The median age of onset of symptoms was 62.5 years. Most were male (64%) and had bilateral eye involvement (64%). The commonest presentation was vitritis in 12 patients, with a median delay of 4 months before diagnosis. In all, 10 patients had B-cell lymphoma, three patients T-cell lymphoma and one null-cell. Four patients had prior systemic lymphoma. Eight patients had primary central nervous system non-Hodgkin's lymphoma (PCNSL). Treatment included combined radiation to the eye and chemotherapy in 10 patients. Complications of radiotherapy included cataract in five (50%), dry eyes in four (40%), punctate keratopathy in two (20%), radiation retinopathy in two (20%), and optic atrophy in one (10%). A total of 11 patients died of lymphoma (79%). One has residual ocular disease, while two have survived for more than 5 years from initial presentation. Although currently disease free, one of these has a poor visual outcome with acuity less than 6/60 secondary to ocular complications of treatment. Conclusions Our study had 29% with prior systemic lymphoma, 57% associated with PCNSL and 14% with intraocular disease only. Overall survival is low (21%) and relapses common in those surviving beyond 12 months. Visual outcome in survivors is very poor due, in large part, to significant complications from radiotherapy. |
| Databáze: | OpenAIRE |
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