Neurofibromatosis type 2 and multiple sclerosis
| Autor: | Michael Brodhun, Helen Morrison, Steffen K. Rosahl, Oliver Tiedge, Dario-Lucas Helbing |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Multiple sclerosis De novo mutation Nf2 gene General Medicine Schwannoma medicine.disease Comorbidity Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Neurology otorhinolaryngologic diseases medicine 030212 general & internal medicine Neurology (clinical) Neurofibromatosis type 2 business 030217 neurology & neurosurgery |
| Zdroj: | Multiple sclerosis and related disorders. 39 |
| ISSN: | 2211-0356 |
| Popis: | Comorbidity of neurofibromatosis type 2 (NF2) and multiple sclerosis (MS) has rarely been reported. Since immunological mechanisms have been implicated in Nf2, coexistence of the two entities may offer insights into schwannoma pathogenesis with respect to the impact of the immune system. We present the case of a woman with a de novo mutation in the NF2 gene who later developed MS. In addition, we found a significantly higher count of T cells in a laryngeal schwannoma of this patient as compared to a schwannoma removed from a NF2 patient without MS. This finding correlated with a higher growth rate in the case of NF+MS. |
| Databáze: | OpenAIRE |
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