Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin
| Autor: | Jun Liang, Fei Han, Weizhe Qiu, Suxia Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Microarray Esophageal Neoplasms Steroid hormone receptor Angiogenesis Survivin Peroxisome proliferator-activated receptor Biology Pathology and Forensic Medicine Inhibitor of Apoptosis Proteins 03 medical and health sciences 0302 clinical medicine Sirtuin 1 Biomarkers Tumor Humans Receptor Aged chemistry.chemical_classification Aged 80 and over Cell Biology Middle Aged Prognosis Immunohistochemistry ErbB Receptors 030104 developmental biology chemistry Tumor progression Apoptosis 030220 oncology & carcinogenesis Lymphatic Metastasis Cancer research Carcinoma Squamous Cell lipids (amino acids peptides and proteins) Female Esophageal Squamous Cell Carcinoma Neoplasm Grading |
| Zdroj: | Pathology, research and practice. 214(5) |
| ISSN: | 1618-0631 |
| Popis: | SIRT1 (silent mating type information regulation 2 homolog 1) is an enzyme that deacetylates proteins that contributes to cell survival and angiogenesis. Peroxisome proliferator-activated receptor Ƴ (PPAR Ƴ) is a member of the nuclear steroid hormone receptor superfamily and regulates cell apoptosis and proliferation. The functional roles of SIRT1 and PPAR Ƴ in tumor progression remain controversy. This study aims to investigate the roles of SIRT1 and PPAR Ƴ in esophageal squamous cell carcinoma (ESCC), as well as correlation with expression of EGFR and Survivin. Here, we analyzed the protein expression of SIRT1 and PPAR Ƴ in tumor microarray with ESCC and its associations with clinicopathological parameters and overall survival. Both SIRT1 and PPAR Ƴ were highly expressed in tumor tissues comparing with non-cancerous epithelium. High expression of SIRT1 was positively correlated with advanced TNM stage and poor outcome, while high expression of PPAR Ƴ was positively related with tumor grading, not with patients' prognosis. In addition, the high expression of SIRT1 was positively correlated with overexpression of EGFR, not related with PPAR Ƴ or Survivin expression status. These data suggests SIRT1 may serve as a predictor of poor prognosis in ESCC, and its mediated tumor-promoting role might be associated with the overexpression of EGFR protein in ESCC. |
| Databáze: | OpenAIRE |
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