Thalamic neurometabolic alterations in tremulous Parkinson's disease: A preliminary proton MR spectroscopy study

Autor: Federico Rocca, Maurizio Morelli, Manuela Caracciolo, Gennarina Arabia, Maria Salsone, Aldo Quattrone, Andrea Quattrone, Gaetano Barbagallo, Umberto Sabatini, Fabiana Novellino, Rita Nisticò, Andrea Cherubini
Rok vydání: 2017
Předmět:
Male
Pathology
Magnetic Resonance Spectroscopy
Parkinson's disease
Choline
030218 nuclear medicine & medical imaging
chemistry.chemical_compound
0302 clinical medicine
Thalamus
Tremor
Medicine
medicine.diagnostic_test
biology
Essential tremor
Glutamate receptor
Discriminant Analysis
Parkinson Disease
Tremor-dominant
Middle Aged
Neurology
Female
endocrine system
medicine.medical_specialty
Creatine
03 medical and health sciences
Magnetic resonance imaging
Humans
Aged
Dopamine transporter
Tomography
Emission-Computed
Single-Photon
Proton magnetic resonance spectroscopy
Aspartic Acid
Dopamine Plasma Membrane Transport Proteins
business.industry
medicine.disease
Logistic Models
ROC Curve
nervous system
chemistry
biology.protein
Neurology (clinical)
Geriatrics and Gerontology
business
Nuclear medicine
Essential tremor with resting tremor
030217 neurology & neurosurgery
Emission computed tomography
Zdroj: Parkinsonism & related disorders 43 (2017): 78–84. doi:10.1016/j.parkreldis.2017.07.028
info:cnr-pdr/source/autori:Barbagallo, Gaetano; Arabia, Gennarina; Morelli, Maurizio; Nistico, Rita; Novellino, Fabiana; Salsone, Maria; Rocca, Federico; Quattrone, Andrea; Caracciolo, Manuela; Sabatini, Umberto; Cherubini, Andrea; Quattrone, Aldo/titolo:Thalamic neurometabolic alterations in tremulous Parkinson's disease: A preliminary proton MR spectroscopy study./doi:10.1016%2Fj.parkreldis.2017.07.028/rivista:Parkinsonism & related disorders/anno:2017/pagina_da:78/pagina_a:84/intervallo_pagine:78–84/volume:43
ISSN: 1353-8020
Popis: Introduction The objective of this study was to investigate the thalamic biochemical changes in tremor-dominant Parkinson's disease (tPD) patients in comparison with essential tremor with resting tremor (rET) patients, by using proton MR spectroscopy (1H-MRS). Methods Fourteen tPD patients, 12 rET patients and 10 controls participated in this study. All patients underwent dopamine transporter single-photon emission computed tomography (DAT-SPECT) with 123I-ioflupane, and a short-echo single-voxel 1H-MRS on a 3T scanner. A voxel of 10 × 15 × 10 mm involving the Vim nucleus was acquired in both thalami of all subjects. Peak areas of N-acetyl-aspartate (NAA), creatine (Cr), glycerophosphocholine (Cho), and glutamate (Glu) were measured for each voxel using LCModel. The NAA/Cr, Cho/Cr, and Glu/Cr ratios were then calculated. Results DAT-SPECT was abnormal in tPD patients, whereas it was normal in rET patients. Patients with tPD showed a significant reduction of NAA/Cr and Cho/Cr in the thalami compared to rET and healthy controls; whereas there were no significant differences between rET patients and controls. The combination of thalamic NAA/Cr and Cho/Cr ratios showed a 100% accuracy in distinguishing tPD patients from rET patients and controls. Conclusions This study provides preliminary evidence that thalamic neurometabolic abnormalities occur in tremor-dominant phenotype of PD, and suggests that 1H-MRS can help differentiate patients with tPD from those with rET.
Databáze: OpenAIRE
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