Specification of the First Mammalian Cell Lineages In Vivo and In Vitro
| Autor: | Nicolas Plachta, Melanie D. White |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Retroelements
Lineage (evolution) Embryonic Development Cell fate determination Biology In Vitro Techniques General Biochemistry Genetics and Molecular Biology Cell Line Epigenesis Genetic Histones 03 medical and health sciences Mice 0302 clinical medicine Pregnancy Animals Humans Cell Lineage Epigenetics 030304 developmental biology 0303 health sciences Multipotent Stem Cells Stem Cells Totipotent Gene Expression Regulation Developmental Embryo Cell Differentiation DNA Methylation Embryo Mammalian Chromatin Cell biology Body plan Blastocyst PERSPECTIVES Multipotent Stem Cell Female Stem cell 030217 neurology & neurosurgery |
| Zdroj: | Cold Spring Harb Perspect Biol |
| ISSN: | 1943-0264 |
| Popis: | Our understanding of how the first mammalian cell lineages arise has been shaped largely by studies of the preimplantation mouse embryo. Painstaking work over many decades has begun to reveal how a single totipotent cell is transformed into a multilayered structure representing the foundations of the body plan. Here, we review how the first lineage decision is initiated by epigenetic regulation but consolidated by the integration of morphological features and transcription factor activity. The establishment of pluripotent and multipotent stem cell lines has enabled deeper analysis of molecular and epigenetic regulation of cell fate decisions. The capability to assemble these stem cells into artificial embryos is an exciting new avenue of research that offers a long-awaited window into cell fate specification in the human embryo. Together, these approaches are poised to profoundly increase our understanding of how the first lineage decisions are made during mammalian embryonic development. |
| Databáze: | OpenAIRE |
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