Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer
| Autor: | Alberto Ouro, Antía Custodia, Marta Aramburu-Nuñez, Upasana Das Adhikari, Ana Gomez-Larrauri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Ceramide Programmed cell death Medicine (General) Cell cycle checkpoint shingosine 1-phosphate (S1P) ceramide 1-phosphate (C1P) Cell Antineoplastic Agents Review Biology Ceramides medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine R5-920 Neoplasms medicine Humans cancer Inflammation Sphingolipids Cell growth ceramide (Cer) apoptosis sphingolipids (Sphs) General Medicine Sphingolipid Cell biology carbohydrates (lipids) cell proliferation 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Second messenger system lipids (amino acids peptides and proteins) deoxy-sphingolipids Carcinogenesis |
| Zdroj: | Medicina, Vol 57, Iss 729, p 729 (2021) Medicina |
| ISSN: | 1648-9144 |
| Popis: | Sphingolipids are both structural molecules that are essential for cell architecture and second messengers that are involved in numerous cell functions. Ceramide is the central hub of sphingolipid metabolism. In addition to being the precursor of complex sphingolipids, ceramides induce cell cycle arrest and promote cell death and inflammation. At least some of the enzymes involved in the regulation of sphingolipid metabolism are altered in carcinogenesis, and some are targets for anticancer drugs. A number of scientific reports have shown how alterations in sphingolipid pools can affect cell proliferation, survival and migration. Determination of sphingolipid levels and the regulation of the enzymes that are implicated in their metabolism is a key factor for developing novel therapeutic strategies or improving conventional therapies. The present review highlights the importance of bioactive sphingolipids and their regulatory enzymes as targets for therapeutic interventions with especial emphasis in carcinogenesis and cancer dissemination. |
| Databáze: | OpenAIRE |
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