Initiation of Aspirin Therapy Modulates Angiogenic Protein Levels in Women with Breast Cancer Receiving Tamoxifen Therapy

Autor:	Jamie E. Levis, Joan Skelly, Hyman B. Muss, Chris E. Holmes, Jagoda Jasielec
Rok vydání:	2013
Předmět:	Adult Blood Platelets Vascular Endothelial Growth Factor A medicine.medical_specialty Angiogenesis Breast Neoplasms Pharmacology Preliminary Report TSP‐1 tamoxifen General Biochemistry Genetics and Molecular Biology Thrombospondin 1 chemistry.chemical_compound breast cancer Breast cancer Internal medicine Thrombin receptor medicine Preliminary Reports Humans Platelet Platelet activation Angiogenic Proteins General Pharmacology Toxicology and Pharmaceutics Research Articles Aged Aspirin biology business.industry General Neuroscience General Medicine Middle Aged Platelet Activation medicine.disease VEGF Vascular endothelial growth factor Tamoxifen Endocrinology chemistry biology.protein Female Receptors Thrombin Cyclooxygenase business medicine.drug
Zdroj:	Clinical and Translational Science
ISSN:	1752-8062 1752-8054
DOI:	10.1111/cts.12070
Popis:	Aspirin has a range of antineoplastic properties linked to inhibition of cyclooxygenase enzymes in tumor cells, platelet inhibition and to inhibition of angiogenesis. We undertook a prospective study to determine the influence of a 45‐day course of aspirin therapy on circulating and intraplatelet levels of selected proangiogenic (vascular endothelial growth factor [VEGF]) and antiangiogenic (thrombospondin‐1 [TSP‐1]) proteins, and platelet protein release in women diagnosed with breast cancer who were receiving tamoxifen therapy. Initiation of aspirin therapy increases serum and intraplatelet levels of TSP‐1 without a corresponding increase in VEGF levels. Following aspirin therapy, VEGF levels decreased (relative to pretreatment levels) while TSP‐1 returned to pretreatment levels. Plasma TSP‐1 and VEGF levels did not change on aspirin therapy. Aspirin use also decreased thrombin receptor mediated release of TSP‐1 and VEGF from platelets. The selective impact on platelet angiogenic protein content and release supports one mechanism by which aspirin can modify the angiogenic balance in women receiving tamoxifen therapy. Aspirin therapy appears to favor an overall antiangiogenic balance in women with breast cancer who are receiving tamoxifen therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06a51c6ca66a1c786dc814f6399b085 https://doi.org/10.1111/cts.12070 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.