| Autor: |
Alona Bin-Nun, Rawan Abu-Omar, Irina Shchors, Francis Mimouni, Cathy Hammerman |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
American journal of perinatology. 29(14) |
| ISSN: |
1098-8785 |
| Popis: |
Objective Perinatal thrombocytopenia has been shown to affect responsiveness to therapeutic ductal closure with cyclooxygenase (COX) inhibitors. This has not been studied in responsiveness to acetaminophen, which has less effect on platelet function. The objective of this study was to evaluate whether thrombocytopenia affects ductal responsiveness to acetaminophen. Study Design This study was a retrospective review of preterm neonates Results We studied 254 infants. Fifty-seven of these (22%) had a hemodynamically significant patent ductus arteriosus (hsPDA) and were treated with acetaminophen. Forty (70%) of those treated responded with ductal closure after one to two courses of acetaminophen. Seventeen infants were considered nonresponsive, requiring the addition of ibuprofen and/or surgical ligation. Sixty seven of the 254 infants (26%) developed moderate thrombocytopenia (platelets Conclusions This study is the first to document that, in contrast to the COX inhibitors, there is no association between early neonatal thrombocytopenia and ductal therapeutic responsiveness to acetaminophen. Key Points |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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