Clostridium difficile infections related to antibiotic use and infection control facilities in two university hospitals
| Autor: | L Smaabrekke, Dag Berild, Michaela Lelek, Signe Ringertz, E.M Stahlsberg, D.S Halvorsen |
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| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Diarrhea medicine.medical_specialty medicine.drug_class Antibiotics Prevalence Hospitals University Internal medicine Medicine Infection control Humans Intensive care medicine Antibacterial agent Bed Occupancy Infection Control business.industry Clostridioides difficile Norway Incidence (epidemiology) Incidence Clindamycin General Medicine Clostridium difficile Length of Stay bacterial infections and mycoses Anti-Bacterial Agents Infectious Diseases Clostridium Infections medicine.symptom business medicine.drug |
| Zdroj: | The Journal of hospital infection. 54(3) |
| ISSN: | 0195-6701 |
| Popis: | We investigated whether a reduction in antibiotic use at the Aker University Hospital (Aker) led to a reduction in Clostridium difficile-associated diarrhoea (CDAD). We compared the incidence of CDAD in Aker and Tromsoe University Hospitals (Tromsoe) and related it to antibiotic use and facilities for infection control between 1993-2001. For this purpose we also performed point prevalence studies. Total antibiotic use was the same in the two hospitals. In spite of a reduction in the use of broad-spectrum antibiotics in Aker the incidence of CDAD increased during 1993-1999. In Tromsoe the use of broad-spectrum antibiotics and clindamycin was two to three times higher than in Aker, but until 1999 the incidence of CDAD remained constant and only half that of Aker. After 1999 the incidence of CDAD was halved in Aker, and increased three-fold in Tromsoe. Point prevalence studies in 2001 revealed an equal prevalence of antibiotic-associated diarrhoea. The facilities for infection control were better in Tromsoe. The percentage of single rooms were 8% in Aker and 14% in Tromsoe, and the percentage of single rooms with a WC was 6% in Aker and 12% in Tromsoe. The bed occupancy was much higher in Aker than in Tromsoe. Lack of facilities for infection control and higher bed occupancy could have contributed to the higher incidence of CDAD in Aker in spite of decreased use of broad-spectrum antibiotics and clindamycin. To limit CDAD in hospitals the focus must be on both rational antibiotic use and infection control. |
| Databáze: | OpenAIRE |
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