MR parkinsonism index predicts vertical supranuclear gaze palsy in patients with PSP-parkinsonism
| Autor: | Fabiana Novellino, Domenico Bosco, David R. Williams, Salvatore Nigro, Carmelina Chiriaco, Basilio Vescio, Maurizio Morelli, Pierfrancesco Pugliese, Giuseppe Nicoletti, R. Nisticò, Franco Pucci, Manuela Caracciolo, Gennarina Arabia, Maria Salsone, Aldo Quattrone |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Postural instability Article 03 medical and health sciences 0302 clinical medicine Ocular Motility Disorders Parkinsonian Disorders medicine Humans In patient parkinsonism Aged Neurologic Examination Observer Variation Vertical supranuclear gaze palsy medicine.diagnostic_test Parkinsonism Follow up studies Brain Magnetic resonance imaging MR Middle Aged medicine.disease Prognosis Magnetic Resonance Imaging eye diseases Surgery 030104 developmental biology Clinical diagnosis Biomarker (medicine) Female Neurology (clinical) Radiology Supranuclear Palsy Progressive Psychology 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Neurology Neurology (Online) 87 (2016): 1266–1273. doi:10.1212/WNL.0000000000003125 info:cnr-pdr/source/autori:Aldo Quattrone, Maurizio Morelli, David R. Williams, Basilio Vescio, Gennarina Arabia, Salvatore Nigro, Giuseppe Nicoletti, Maria Salsone, Fabiana Novellino, Rita Nisticò, Franco Pucci, Carmelina Chiriaco, Pierfrancesco Pugliese, Domenico Bosco, Manuela Caracciolo/titolo:MR parkinsonism index predicts vertical supranuclear gaze palsy in patients with PSP-parkinsonism./doi:10.1212%2FWNL.0000000000003125/rivista:Neurology (Online)/anno:2016/pagina_da:1266/pagina_a:1273/intervallo_pagine:1266–1273/volume:87 |
| ISSN: | 1526-632X |
| DOI: | 10.1212/WNL.0000000000003125 |
| Popis: | Objective: To identify a biomarker for predicting the appearance of vertical supranuclear gaze palsy (VSGP) in patients affected by progressive supranuclear palsy–parkinsonism (PSP-P). Methods: Twenty-four patients with PSP-P were enrolled in the current study. Patients were clinically followed up every 6 months until the appearance of VSGP or the end of the follow-up (4 years). Participants underwent MRI at baseline and at the end of follow-up. Magnetic resonance parkinsonism index (MRPI), an imaging measure useful for diagnosing PSP, was calculated. Results: Twenty-one patients with PSP-P completed follow-up, and 3 patients dropped out. Eleven of 21 patients with PSP-P developed VSGP after a mean follow-up period of 28.5 months (range 6–48 months), while the remaining 10 patients with PSP-P did not develop VSGP during the 4-year follow-up period. At baseline, patients with PSP-P who later developed VSGP had MRPI values significantly higher than those of patients not developing VSGP without overlapping values between the 2 groups. MRPI showed a higher accuracy (100%) in predicting VSGP than vertical ocular slowness (accuracy 33.3%) or postural instability with or without vertical ocular slowness (accuracy 71.4% and 42.9%, respectively). Conclusions: Our study demonstrates that MRPI accurately predicted, on an individual basis, the appearance of VSGP in patients with PSP-P, thus confirming clinical diagnosis in vivo. |
| Databáze: | OpenAIRE |
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