Comparison of vascular response between everolimus-eluting stent and bare metal stent implantation in ST-segment elevation myocardial infarction assessed by optical coherence tomography
| Autor: | Kenichi Komukai, Yasutsugu Shiono, Kumiko Hirata, Makoto Orii, Tomoyuki Yamaguchi, Keisuke Satogami, Atsushi Tanaka, Takashi Yamano, Takashi Akasaka, Hironori Kitabata, Takashi Kubo, Yong Liu, Toshio Imanishi, Yasushi Ino, Kunihiro Shimamura, Yoshiki Matsuo, Takashi Tanimoto |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Bare-metal stent medicine.medical_specialty Iohexol medicine.medical_treatment Myocardial Infarction Contrast Media Coronary Angiography Restenosis Risk Factors Internal medicine medicine Humans ST segment Radiology Nuclear Medicine and imaging Everolimus Prospective Studies cardiovascular diseases Myocardial infarction Thrombus Aged business.industry Stent Percutaneous coronary intervention Drug-Eluting Stents General Medicine equipment and supplies medicine.disease Treatment Outcome surgical procedures operative Cardiology Female Stents Cardiology and Cardiovascular Medicine business Tomography Optical Coherence medicine.drug |
| Zdroj: | European Heart Journal - Cardiovascular Imaging. 16:513-520 |
| ISSN: | 2047-2412 2047-2404 |
| DOI: | 10.1093/ehjci/jeu227 |
| Popis: | Aims The long-term safety of second-generation everolimus-eluting stents (EESs) in ST-segment elevation myocardial infarction (STEMI) remains unclear. The aim of this study was to evaluate the late vascular response after stent implantation in STEMI between EES and bare-metal stent (BMS) by using optical coherence tomography (OCT). Methods and results A prospective OCT examination was performed in 102 patients at 10 months after stent implantation for treatment of STEMI. A total of 1253 frames with 12 772 struts in 61 EESs and 776 frames with 8594 struts in 41 BMSs were analysed. There were no significant differences in the percentage of uncovered struts (2.1 ± 2.8 vs. 1.7 ± 2.7%, P = 0.422) and malapposed struts (0.7 ± 1.3 vs. 0.6 ± 1.2%, P = 0.756) between EES and BMS. The frequency of intra-stent thrombus was comparable between the two stents (13 vs. 10%, P = 0.758). The mean neointimal thickness was smaller in EES compared with BMS (104 ± 39 vs. 388 ± 148 µm, P < 0.001). In-segment binary restenosis and target lesion revascularization was less often seen in EES compared with BMS (3 vs. 17%, P = 0.028 and 2 vs. 12%, P = 0.037, respectively). Conclusion When compared with BMS, EES showed a lower rate of stent restenosis, similar frequency of neointimal coverage, stent malapposition, and intra-stent thrombus at 10 months after stent implantation in STEMI. Our results suggest the safety and effectiveness of EES in primary percutaneous coronary intervention for STEMI patients. |
| Databáze: | OpenAIRE |
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