Hemorrheological Indices, Catecholamines, Neuropeptide Y and Serotonin in Patients with Essential Hypertension
| Autor: | Kochmański M, J Lewandowski, Andrzej Januszewicz, Włodzimierz Januszewicz, Ignatowska-Switalska H, Lapiński M, Wocial B, H. Berent, Kuczyńska K |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Erythrocyte Aggregation Male Serotonin medicine.medical_specialty Epinephrine Platelet Aggregation Blood viscosity Hematocrit Essential hypertension Erythrocyte aggregation Norepinephrine Sex Factors Internal medicine Internal Medicine medicine Humans Erythrocyte deformability Sympathoadrenal system Neuropeptide Y Platelet activation medicine.diagnostic_test business.industry Fibrinogen General Medicine Middle Aged beta-Thromboglobulin Neuropeptide Y receptor medicine.disease Endocrinology Hypertension Female Rheology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Blood Pressure. 6:203-208 |
| ISSN: | 1651-1999 0803-7051 |
| DOI: | 10.3109/08037059709062070 |
| Popis: | Hemorrheological and humoral abnormalities and excessive platelet activity can predict the development of cardiovascular complications in patients with essential hypertension. A study was conducted to assess the influence of gender on these factors and the interrelations between changes in hemorrheology and the sympatho-adrenal system in 54 patients (18 women, 36 men) with essential hypertension (aged 39.6 +/- 9.7 years) and 25 healthy volunteers (10 women, 15 men; aged 36.0 +/- 7.2 years). A decrease in erythrocyte deformability (p < 0.01) was found in the hypertensive men compared with the hypertensive women. Hematocrit (p < 0.01), blood viscosity at the shear rates of 0.3 s-1 (p < 0.01) and 6 s-1 (p < 0.01), plasma viscosity (p < 0.01), erythrocyte aggregation (p < 0.01), and neuropeptide Y (p < 0.02) concentrations were higher in the hypertensive men than in the hypertensive women. A positive correlation between blood fibrinogen and serotonin was found in the pooled hypertensive group and in the hypertensive men (p < 0.01) and between blood viscosity (shear rate 6 s-1) and neuropeptide Y in the pooled hypertensive group (p < 0.01). Neuropeptide Y correlated with filtration time of 1 mL blood in the hypertensive men (p < 0.05) and in the pooled normotensive group (p < 0.01) and with beta-thromboglobulin in the hypertensive women (p < 0.001). A positive correlation was also found in the hypertensive men between erythrocyte and platelet aggregation (p < 0.01) and between beta-thromboglobulin and adrenaline (p < 0.01). Hemorrheological and humoral abnormalities are more pronounced in men than in women with essential hypertension and may contribute to the increased incidence of cardiovascular events in men. |
| Databáze: | OpenAIRE |
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