Double-responsive hyaluronic acid-based prodrugs for efficient tumour targeting
| Autor: | Som Akshay Jain, Arianna Gennari, Francesco Rosso, Manlio Barbarisi, Rosario Vincenzo Iaffaioli, Alfonso Barbarisi, Vincenzo Quagliariello, Nicola Tirelli |
|---|---|
| Přispěvatelé: | Quagliariello, Vincenzo, Gennari, Arianna, Akshay Jain, Som, Rosso, Francesco, Vincenzo Iaffaioli, Rosario, Barbarisi, Alfonso, Barbarisi, Manlio, Tirelli, Nicola |
| Rok vydání: | 2021 |
| Předmět: |
Male
Materials science medicine.medical_treatment Tumour targeting Bioengineering Mice SCID Pharmacology Biomaterials Mice chemistry.chemical_compound Drug Delivery Systems Neoplasms LNCaP Hyaluronic acid medicine Animals Prodrugs Hyaluronic Acid Micelles Chemotherapy Cancer Prodrug medicine.disease chemistry Targeted drug delivery Mechanics of Materials Quercetin |
| Zdroj: | Materials Science and Engineering: C. 131:112475 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2021.112475 |
| Popis: | Hyaluronic acid (HA)-based prodrugs bearing double-responsive (acid pH or oxidation) boronates of catechol-containing drugs were used to treat xenografted human prostate tumours (LNCaP) in SCID mice. The HA prodrugs accumulated significantly only in tumours (impressively, up to 40% of the injected dose after 24 h) and in liver, with negligible – actually anti-inflammatory - consequences in the latter. A quercetin-HA prodrug significantly slowed down tumour growth, in a dose-dependent fashion and with a much higher efficacy (up to 4 times) than equivalent doses of free quercetin. In short, boronated HA appears to be a very promising platform for targeted chemotherapy. |
| Databáze: | OpenAIRE |
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