The Modifying Effect of Age on Survival in Parkinson’s Disease: A Population-Based Cohort Study
| Autor: | Judith Tsamir, Nir Giladi, Baruch El-Ad, Chava Peretz, Tanya Gurevich, Beatriz Hemo, Violetta Rozani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Parkinson's disease Epidemiology Population Disease 030501 epidemiology Cohort Studies 03 medical and health sciences Population based cohort 0302 clinical medicine Internal medicine medicine Humans Reference population education Aged Aged 80 and over education.field_of_study business.industry Age Factors Parkinson Disease Middle Aged medicine.disease Survival Rate Standardized mortality ratio Population Surveillance Cohort Health maintenance Female Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Neuroepidemiology. 53:13-19 |
| ISSN: | 1423-0208 0251-5350 |
| Popis: | Background: To estimate the survival of a population-based cohort of Parkinson’s disease (PD) patients stratified by age and sex over a 13-year period. Methods: The dynamic PD cohort included 6,622 incident PD patients who initiated anti-parkinsonian medications at age >40 years. The reference population (n = 401,498) consisted of members of a large health maintenance organization. We estimated the PD patients’ death risk and sex- and age-specific standardized mortality ratio (SMR). Results: During a follow-up of 5.2 ± 3.3 years, 36% of the cohort died. Older age at first PD treatment was associated with a 55% increase in mortality (for 5-year increase, p < 0.01). More PD patients died when compared to the same age and sex reference population in all age groups, with significant results at age groups >60 years at first treatment. The age-pooled SMR was twofold (SMR for the males = 2.05, 95% CI 1.73–2.42; SMR females = 2.13, 95% CI 1.74–2.62). The highest excess death for males was 2.5-fold for those aged 60–69 years, decreasing to twofold for those in the age range 70–79 years and to 1.5-fold for those aged 80+ years. A similar trend was found among females. Conclusion: Our large-scale cohort enabled us to find an age-differential standardized death risk among PD patients, with the largest increased risk at ages 60–69 years. Comorbidities and other contributory factors warrant further investigation. |
| Databáze: | OpenAIRE |
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