OCT-Based Quantification and Classification of Optic Disc Structure in Glaucoma Patients
| Autor: | Toru Nakazawa, Akiko Matsumoto, Kazuko Omodaka, Tsutomu Kikawa, Kazuichi Maruyama, Masahiro Akiba, Yu Yokoyama, Yukihiro Shiga, Naoko Takada, Hidetoshi Takahashi, Airi Takagi |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Eye Diseases genetic structures Nerve fiber layer Glaucoma lcsh:Medicine Diagnostic Radiology chemistry.chemical_compound 0302 clinical medicine Nerve Fibers Animal Cells Medicine and Health Sciences lcsh:Science Tomography Optic disc structure Neurons Multidisciplinary medicine.diagnostic_test Radiology and Imaging Software Development Software Engineering Middle Aged medicine.anatomical_structure Correlation analysis Engineering and Technology Female Anatomy Cellular Types Glaucoma Open-Angle Tomography Optical Coherence Optic disc Research Article medicine.medical_specialty Computer and Information Sciences Imaging Techniques Ocular Anatomy Optic Disk Research and Analysis Methods Optic Disc 03 medical and health sciences Optical coherence tomography Ocular System Diagnostic Medicine Ophthalmology medicine Humans Aged Reproducibility business.industry Choroid lcsh:R Reproducibility of Results Biology and Life Sciences Retinal Optic Nerve Cell Biology medicine.disease eye diseases Surgery 030104 developmental biology chemistry ROC Curve Cellular Neuroscience 030221 ophthalmology & optometry Eyes lcsh:Q sense organs business Head Neuroscience |
| Zdroj: | PLoS ONE, Vol 11, Iss 8, p e0160226 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Purpose To objectively classify the optic discs of open-angle glaucoma (OAG) patients into Nicolela's four disc types, i.e., focal ischemic (FI), myopic (MY), senile sclerotic (SS), and generalized enlargement (GE), with swept-source optical coherence tomography (SS-OCT). Methods This study enrolled 113 eyes of 113 OAG patients (mean age: 62.5 ± 12.6; Humphrey field analyzer-measured mean deviation: -9.4 ± 7.3 dB). Newly developed software was used to quantify a total of 20 optic disc parameters in SS-OCT (DRI OCT-1, TOPCON) images of the optic disc. The most suitable reference plane (RP) above the plane of Bruch’s membrane opening was determined by comparing, at various RP heights, the SS-OCT-measured rim parameters and spectral-domain OCT-measured circumpapillary retinal nerve fiber layer thickness (cpRNFLT), with Pearson's correlation analysis. To obtain a discriminant formula for disc type classification, a training group of 72 eyes of 72 OAG patients and a validation group of 60 eyes of 60 OAG patients were set up. Results Correlation with cpRNFLT differed with disc type and RP height, but overall, a height of 120 μm minimized the influence of disc type. Six parameters were most significant for disc type discrimination: disc angle (horizontal), average cup depth, cup/disc ratio, rim-decentering ratio, average rim/disc ratio (upper and lower nasal). Classifying the validation group with these parameters returned an identification rate of 80.0% and a Cohen’s Kappa of 0.73. Conclusion Our new, objective SS-OCT-based method enabled us to classify glaucomatous optic discs with high reproducibility and accuracy. |
| Databáze: | OpenAIRE |
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