Lateral line: From water waves to brain waves
| Autor: | Brian M. McDermott |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Acoustics Lateral line Fishes Water Brain waves Biology Brain Waves General Biochemistry Genetics and Molecular Biology Article Lateral Line System 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Fish Animals Line (text file) General Agricultural and Biological Sciences 030217 neurology & neurosurgery Swimming |
| Zdroj: | Curr Biol |
| ISSN: | 1879-0445 |
| Popis: | Animals have a remarkable ability to use local cues to orient in space in the absence of a panoramic fixed reference frame. Here we use the mechanosensory lateral line in larval zebrafish to understand rheotaxis, an innate oriented swimming evoked by water currents. We generated a comprehensive light-microscopy cell-resolution projectome of lateralis afferent neurons (LANs), and used clustering techniques for morphological classification. We find surprising structural constancy among LANs. Laser-mediated microlesions indicate that precise topographic mapping of lateral-line receptors is not essential for rheotaxis. Recording neuronal-activity during controlled mechanical stimulation of neuromasts reveals unequal representation of water-flow direction in the hindbrain. We explored potential circuit architectures constrained by anatomical and functional data to suggest a parsimonious model under which the integration of lateralized signals transmitted by direction-selective LANs underlies the encoding of water-flow direction in the brain. These data provide a new framework to understand how animals use local mechanical cues to orient in space. |
| Databáze: | OpenAIRE |
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