Effect of Prenatal Administration of Aluminum and Parathyroid Hormone on Fetal Development in the Rat
| Autor: | K.M. McCormack, Jerry B. Hook, Gilbert H. Mayor, L. D. Ottosen, Stuart M. Sprague, V. L. Sanger |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Parathyroid hormone chemistry.chemical_element Gestational Age Calcium General Biochemistry Genetics and Molecular Biology Fetus Pregnancy Internal medicine medicine Protein biosynthesis Animals Fetal Death Maternal-Fetal Exchange Embryogenesis Gestational age Drug Synergism medicine.disease Teratology Rats Teratogens Endocrinology chemistry Parathyroid Hormone Female Aluminum |
| Zdroj: | Experimental Biology and Medicine. 161:74-77 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-161-40493 |
| Popis: | SummaryOral aluminum (Al) exposure is a consequence of the element's presence in food, cosmetics, drinking water and its use in preparations administered therapeutically in large quantities as antacids or phosphate binders. Al is neurotoxic in animals and elevated concentrations of Al have been detected in brains of patients with certain encephalopathies. Protein synthesis, ribosomal RNA content and microtubular polymerization may be altered by Al. Since there are critical periods of protein synthesis and cellular division during embryonic development it was of interest to determine the teratogenic potential of Al. Since parathyroid hormone (PTH) increases tissue Al concentrations the effects of combined treatment of Al and PTH were also evaluated. Rats were maintained on diet supplemented with Al and/or calcium and treated with PTH or vehicle from day 6 of pregnancy through day 19, when fetuses were removed by Caesarean section. Combined or separate treatment with PTH and Al did not alter the number of l... |
| Databáze: | OpenAIRE |
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