Autologous mesenchymal stem cells in chronic spinal cord injury
| Autor: | Yanish Bhanot, Sujay Rao, C R Radhika, Sudheer Balaraju, K V Satish Kumar, Debapriya Ghosh |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Central nervous system Pilot Projects Mesenchymal Stem Cell Transplantation Transplantation Autologous Young Adult medicine Humans Young adult Spinal cord injury Injections Spinal Spinal Cord Injuries business.industry Regeneration (biology) Mesenchymal stem cell Laminectomy General Medicine Middle Aged medicine.disease Surgery Transplantation medicine.anatomical_structure Treatment Outcome Chronic Disease Tissue and Organ Harvesting Female Neurology (clinical) Stem cell business Follow-Up Studies |
| Zdroj: | British journal of neurosurgery. 25(4) |
| ISSN: | 1360-046X |
| Popis: | Spinal cord injury (SCI) occurs in the most productive part of life. Treatment options for treatment of chronic SCI are few and have limited impact on clinical outcome. Central nervous system (CNS) has limited intrinsic regeneration capability. The study included patients with chronic complete SCI. Previously harvested autologous mesenchymal stem cells were administered at the site of injury after a laminectomy. Follow-up was done by a neutral examiner not involved in the surgery every 3 months. One patient had improvement in motor power. Two patients had a patchy improvement in pin prick sensation below the level of injury. Three different, progressively increasing doses did not result in improvement in the clinical outcome. Though the administration of allogenic human mesenchymal stem cells is safe in patients with SCI, it may not be efficacious; especially in patients with chronic SCI. |
| Databáze: | OpenAIRE |
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