Contribution of serum lipids as effect modifiers to a relationship between mean arterial pressure and coronary heart disease in Chinese rural population: the Henan Rural Cohort Study
| Autor: | Runqi Tu, Haiqing Zhang, Dou Qiao, Yuqian Li, Zhongyan Tian, Chongjian Wang, Gongyuan Zhang, Xia Zhang, Kai Hu, Yanhua Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Rural Population Mean arterial pressure China Adolescent Epidemiology Population Blood lipids Coronary Disease Logistic regression Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Medicine Humans Arterial Pressure 030212 general & internal medicine coronary heart disease education Aged Original Research education.field_of_study business.industry General Medicine Middle Aged Sphygmomanometers Lipids Blood pressure Cross-Sectional Studies Logistic Models serum lipids Quartile Hypertension mean arterial pressure Female Rural area business 030217 neurology & neurosurgery Demography Cohort study |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesThe aim of this study was to evaluate the relationship between mean arterial pressure (MAP) and coronary heart disease (CHD) in Chinese rural population. In addition, we hypothesised that this relationship might be mediated by some degree of serum lipids.DesignThis is a cross-sectional study.SettingThe participants were from the Henan Rural Cohort Study, initiated in five rural areas (Tongxu county of Kaifeng city, Yima county of Sanmenxia city, Suiping county of Zhumadian city, Xinxiang county of Xinxiang city and Yuzhou county of Xuchang city) in Henan Province, China, during July 2015 and September 2017.ParticipantsThe study included 39 020 subjects aged 18–79 years as current research population.Outcome measuresSystolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using an electronic sphygmomanometer. MAP was calculated by one-third SBP plus two-thirds DBP. The study used restricted cubic splines and logistic regression models to evaluate the ORs and 95% CIs. Mediation analysis using bootstrap was performed to examine the contribution of serum lipids to MAP-related CHD.ResultsThe adjusted OR (95% CI) for the highest MAP quartile with the risk of CHD was 1.45 (1.24 to 1.69) compared with the lowest quartile. Simultaneously, each 1-SD increment in MAP was significantly associated with a 12% increased risk of CHD. A linear dose–response relationship between MAP and CHD was found (p value for non-linear=0.1169) in the fully adjusted model. We further reported that 36.07% of proportion explained risk of CHD was mediated through serum lipids.ConclusionsIncreased MAP was a significant marker of CHD in Chinese rural population. Meanwhile, the relationship was mediated by some degree of serum lipids, and triglyceride was the strongest mediator.Trial registration numberHenan Rural Cohort study has been registered at Chinese Clinical Trial Register (ChiCTR-OOC-15006699) and the stage it relates to is Post-results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|