Impact of Early, Low-Dose Factor VIIa on Subsequent Transfusions and Length of Stay in Cardiac Surgery
| Autor: | Brigid C. Flynn, Abigail Houchin, Tian Wang, Lauren Sutherland, Trip Zorn, Vivek K. Moitra, Shuang Wang, Akshit Sharma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Resuscitation Blood Loss Surgical Factor VIIa 030204 cardiovascular system & hematology Postoperative Hemorrhage law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030202 anesthesiology Interquartile range law medicine Humans Dosing Cardiac Surgical Procedures Retrospective Studies Factor VII business.industry Length of Stay medicine.disease Intensive care unit Thrombosis Recombinant Proteins Cardiac surgery Anesthesiology and Pain Medicine Treatment Outcome chemistry Anesthesia Observational study Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of cardiothoracic and vascular anesthesia. 36(1) |
| ISSN: | 1532-8422 |
| Popis: | OBJECTIVE Recombinant factor VII (rFVIIa) is used to treat cardiac surgical bleeding in an off-label manner. However, optimal dosing and timing of administration to provide efficacious yet safe outcomes remain unknown. DESIGN Retrospective, observational study. SETTING Tertiary care academic center. PARTICIPANTS Cardiac surgical patients (N = 214) who received low-dose rFVIIa for cardiac surgical bleeding. INTERVENTIONS Patients were allocated into one of three groups based on timing of rFVIIa administration during the course of bleeding resuscitation based on the number of hemostatic products given before rFVIIa administration: group one = ≤one products (n = 82); group two = two-to-four products (n = 73); and group three= ≥five products (n = 59). MEASUREMENTS AND MAIN RESULTS Patients who received low-dose rFVIIa later in the course of bleeding resuscitation (group three) had longer intensive care unit stays (p = 0.014) and increased incidence of postoperative renal failure when compared with group one (p = 0.039). Total transfusions were lowest in patients who received rFVIIa early in the course of resuscitation (group one) (median, two [interquartile range (IQR), 1-4.75]) and highest in group three (median, 11 [IQR, 8-14]; p < 0.001). Subsequent blood product transfusions after rFVIIa administration were highest in group two (p = 0.003); however, the median for all three groups was two products. There were no differences in thrombosis, reexplorations, or mortality in any of the groups. CONCLUSIONS This study identified no differences in adverse outcomes based on timing of administration of low-dose rFVIIa for cardiac surgical bleeding defined by stage of resuscitation, but the benefits of early administration remain unclear. |
| Databáze: | OpenAIRE |
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