Cochlear hair cell innervation is dependent on a modulatory function of Semaphorin‐3A

Autor: Homero L. Cantu‐Guerra, Michael R. Papazian, Anna L. Gorsky, Nathalie S. Alekos, Adam Caccavano, Nare Karagulyan, Jakob Neef, Stefano Vicini, Tobias Moser, Thomas M. Coate
Rok vydání: 2022
Předmět:
Zdroj: Developmental Dynamics. 252:124-144
ISSN: 1097-0177
1058-8388
Popis: Proper connectivity between type I spiral ganglion neurons (SGNs) and inner hair cells (IHCs) in the cochlea is necessary for conveying sound information to the brain in mammals. Previous studies have shown that type I SGNs are heterogeneous in form, function and synaptic location on IHCs, but factors controlling their patterns of connectivity are not well understood.During development, cochlear supporting cells and SGNs express Semaphorin-3A (SEMA3A), a known axon guidance factor. Mice homozygous for a point mutation that attenuates normal SEMA3A repulsive activity (Sema3aContrary to the canonical view of SEMA3A as a guidance ligand, our results suggest SEMA3A may regulate SGN excitability in the cochlea, which may influence the morphology and synaptic arrangement of type I SGNs.
Databáze: OpenAIRE
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