The elevated homocysteine stimulates changes of haemostatic function of plasma isolated from breast cancer patients
| Autor: | Edward Bald, Joanna Malinowska, Janusz Piekarski, Magdalena Kedzierska, Rafał Głowacki, Beata Olas, Arkadiusz Jeziorski |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Homocysteine Clinical chemistry Thrombin Time medicine.medical_treatment Clinical Biochemistry Breast Neoplasms Thrombin time Gastroenterology Statistics Nonparametric Fibrin chemistry.chemical_compound Thrombin Breast cancer Risk Factors Internal medicine Fibrinolysis medicine Humans skin and connective tissue diseases Molecular Biology Aged Aged 80 and over Prothrombin time Hemostasis medicine.diagnostic_test biology business.industry Carcinoma Ductal Breast Cell Biology General Medicine Middle Aged medicine.disease chemistry Case-Control Studies biology.protein Female business medicine.drug |
| Zdroj: | Molecular and Cellular Biochemistry. 355:193-199 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/s11010-011-0854-x |
| Popis: | The aim of our study was to explain the effect of elevated homocysteine (measured by HPLC) on haemostatic activity of plasma from breast cancer patients (fibrin polymerization and lysis; the thrombin and prothrombin time), because homocysteine (Hcys) induces changes in haemostasis, as well blood clotting as fibrinolysis. Patients were hospitalized in Department of Oncological Surgery, Medical University of Lodz, Poland. All patients have not had preadjuvant therapy, and samples from patients were taken before surgery. We observed that changes of selected parameters of haemostatic properties of plasma, e.g., the prothrombin time and thrombin time were prolonged in plasma from invasive breast cancer when compared with the control group (healthy subjects) and patients with benign breast diseases. Our results showed also that the correlation between the increased amount of Hcys and changes of selected parameters of haemostasis in invasive breast cancer patients exists. Considering the data presented in this study, we suggest that the elevated Hcys in invasive breast cancer patients may induce the changes of haemostatic properties of plasma isolated from these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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