Control of apoptosis by Rel/NF-kappaB transcription factors
Autor: | Thomas D. Gilmore, Margaret Barkett |
---|---|
Rok vydání: | 1999 |
Předmět: |
Cancer Research
Cell type Programmed cell death Lymphocyte Apoptosis Biology Virus Replication Neoplasms Genetics medicine Animals Humans Molecular Biology Transcription factor Tissue homeostasis Neurons Tumor Necrosis Factor-alpha Cell Cycle NF-kappa B Transcription Factor RelA Cell cycle medicine.anatomical_structure Immune System Cancer research Signal transduction |
Zdroj: | Oncogene. 18(49) |
ISSN: | 0950-9232 |
Popis: | Apoptosis is a physiological process critical for organ development, tissue homeostasis, and elimination of defective or potentially dangerous cells in complex organisms. Apoptosis can be initiated by a wide variety of stimuli, which activate a cell suicide program that is constitutively present in most vertebrate cells. In diverse cell types, Rel/NF-kappaB transcription factors have been shown to have a role in regulating the apoptotic program, either as essential for the induction of apoptosis or, perhaps more commonly, as blockers of apoptosis. Whether Rel/NF-kappaB promotes or inhibits apoptosis appears to depend on the specific cell type and the type of inducer. An understanding of the role of Rel/NF-kappaB transcription factors in controlling apoptosis may lead to the development of therapeutics for a wide variety of human diseases, including neurodegenerative and immune diseases, and cancer. |
Databáze: | OpenAIRE |
Externí odkaz: |