Long-term evaluation of endothelial function in Kawasaki disease patients
| Autor: | Sérgio Laranjo, Filipa Paramés, Miguel Mota-Carmo, Fátima F. Pinto, Isabel Freitas |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Manometry Population Hyperemia Mucocutaneous Lymph Node Syndrome Pulse Wave Analysis HSM CAR HSM CAR PED Young Adult Hyperaemia Internal medicine medicine Humans Endothelial dysfunction education education.field_of_study business.industry Case-control study General Medicine medicine.disease Coronary arteries medicine.anatomical_structure Case-Control Studies Microvessels Pediatrics Perinatology and Child Health Cardiology Female Kawasaki disease Endothelium Vascular medicine.symptom Cardiology and Cardiovascular Medicine business Complication Systemic vasculitis |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | BackgroundKawasaki disease is an acute systemic vasculitis. Cardiac complications are frequent and include endothelial dysfunction in patients with coronary anomalies. So far, the presence of endothelial dysfunction in patients with no coronary lesions has not been demonstrated. Peripheral arterial tonometry (Endo-PAT) measures the microvascular function in response to local ischaemia and has been validated in adult population, but its use in children is scarce.AimTo evaluate endothelial dysfunction in children as a long-term complication after Kawasaki disease using Endo-PAT.MethodsWe evaluated two groups of subjects: (1) Kawasaki disease patients over 11 years of age, diagnosed for >5 years, with no coronary lesions, or any other risk factors for cardiovascular disease; (2) control group of individuals without cardiovascular risk factors. Patients and controls were clinically accessed. Endo-PAT was performed to determine reactive hyperaemia index and augmentation index.ResultsA total of 35 individuals (21 males, age 21 ± 6 years) were evaluated (group 1: 19; controls: 16). Kawasaki disease patients presented significant lower reactive hyperaemia index (1.68 ± 0.49 versus 2.31 ± 0.53; p = 0.001). Augmentation index was similar in both groups (−10 ± 7 versus −11 ± 5; p > 0.005). Most patients with Kawasaki disease disclosed endothelial dysfunction (68%) compared with only 12% in controls.ConclusionsEndo-PAT is feasible and reproducible in the child population. Endothelial dysfunction is a frequent long-term complication in patients after Kawasaki disease with normal appearing coronary arteries. However, these results need validation in a larger population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|