Role of Ancillary Techniques in Cervical Biopsy and Endocervical Curettage Specimens as Follow-Up to Papanicolaou Test Results Indicating a Diagnosis of Atypical Squamous Cells, Cannot Exclude High-Grade Squamous Intraepithelial Lesion, or High-Grade Squamous Intraepithelial Lesion
| Autor: | Sharon Song, Hadi Shojaei, Taylor M Jenkins, Lauren E. Schwartz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Biopsy Squamous Intraepithelial Lesions Uterine Cervical Neoplasms Papanicolaou stain Cervix Uteri Endocervical curettage Curettage Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Atypical Squamous Cells of the Cervix Humans Medicine Pap test Papillomaviridae Cervical cancer medicine.diagnostic_test business.industry Papillomavirus Infections General Medicine Papanicolaou Test Uterine Cervical Dysplasia 030224 pathology medicine.disease Squamous intraepithelial lesion Dysplasia 030220 oncology & carcinogenesis Immunohistochemistry Female business |
| Zdroj: | Acta Cytologica. 64:155-165 |
| ISSN: | 1938-2650 0001-5547 |
| Popis: | The Papanicolaou (PAP) test is widely used to screen for cervical cancer. All high-grade lesions such as atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H), and high-grade squamous intraepithelial lesion, identified on a PAP test should be followed-up by a confirmatory cervical biopsy. In this review, we discuss the challenges in interpreting cervical tissue specimens and the various ancillary techniques used in the evaluation of cervical dysplasia. Ancillary studies include deeper levels, p16 immunohistochemistry (IHC), human papillomavirus (HPV) testing, and, importantly, cyto-histologic correlation. Of these, p16 IHC is consistently sensitive and specific for detecting HSIL. HPV RNA in situ hybridization (ISH) is a newer technique with excellent sensitivity and specificity for detecting virally infected cells and it may be more broadly applicable to both low- and high-grade squamous intraepithelial lesions. |
| Databáze: | OpenAIRE |
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