Comparison of Epicardial Fat Volume by Computed Tomography in Black Versus White Patients With Acute Chest Pain
| Autor: | U. Joseph Schoepf, Stefan O. Schoenberg, Thomas Henzler, Mathias Meyer, John W. Nance, Rozemarijn Vliegenthart, Andreas Schindler, Fabian Bamberg, Andrew D. McQuiston, Ullrich Ebersberger, Paul Apfaltrer, Francesco Tricarico |
|---|---|
| Přispěvatelé: | Cardiovascular Centre (CVC) |
| Rok vydání: | 2014 |
| Předmět: |
Male
Chest Pain medicine.medical_specialty CLINICAL-PARAMETERS Adipose tissue Computed tomography Chest pain White People AFRICAN-AMERICAN Coronary artery disease RISK-FACTOR Internal medicine medicine Acute chest pain Humans Risk factor PERICARDIAL FAT Retrospective Studies METABOLIC SYNDROME medicine.diagnostic_test business.industry Incidence Middle Aged QUANTIFICATION medicine.disease United States Black or African American ADIPOSE-TISSUE medicine.anatomical_structure Adipose Tissue ATHEROSCLEROSIS Acute Disease Cardiology CORONARY-ARTERY-DISEASE Female Metabolic syndrome medicine.symptom Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business Pericardium Follow-Up Studies CT Artery |
| Zdroj: | American Journal of Cardiology, 113(3), 422-428. EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC |
| ISSN: | 0002-9149 |
| Popis: | Disparities in the risk of coronary artery disease (CAD) between races may be influenced by differences in the thoracic adipose tissue. We compared computed tomography (CT)-derived volumes of epicardial adipose tissue (EAT), mediastinal adipose tissue (MAT), and pericoronary fat thickness (PFT) and correlations with CAD between black and white patients. This institutional review board-approved Health Insurance Portability and Accountability Act-compliant study included 372 age- and gender-matched black versus white patients (186 black, 54 ± 11 years, 50% men; 186 white, 54 ± 11 years, 50% men) who underwent CT for chest pain evaluation. EAT, MAT, and PFT were measured. The amount of coronary calcium was quantified as calcium score. CAD was defined as ≥50% coronary artery narrowing. EAT and MAT volumes were significantly lower in black than white patients (59 [twenty-fifth to seventy-fifth percentile 39 to 84] vs 97 [67 to 132] cm(3) and 44 [27 to 77] vs 87 [52 to 157] cm(3), for both p0.001). Mean PFT in black patients was slightly lower than white patients (17.2 ± 3.2 vs 18.1 ± 3.4 mm, p0.01). The relation between race and extent of adipose tissue remained significant after adjustment for cardiovascular risk factors. Significant correlations were observed between EAT and MAT volumes and calcium score in black and white patients (r = 0.19 to 0.26, p0.01). For both races, the level of thoracic fat measurements was higher in present versus absent coronary calcification. A greater amount of thoracic fat was found with obstructive CAD only in white patients. In conclusion, CT-derived measurements of thoracic fat differ between symptomatic black and white patients, suggesting a differential relation between thoracic adipose tissue and CAD pathophysiology by race. |
| Databáze: | OpenAIRE |
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