Cervico-vaginal mucus (CVM) – an accessible source of immunologically informative biomolecules
| Autor: | Kieran G. Meade, Mounir Adnane, Cliona O'Farrelly |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Immunoglobulin A Antimicrobial peptides Uterus Review Article Cervix Uteri Biology Vaginal mucus Microbiology 03 medical and health sciences Diagnosis medicine Animals Cervix Cervico-vaginal mucus Inflammation General Veterinary Lactoferrin Mucin Mucins Complement System Proteins General Medicine Mucus 030104 developmental biology medicine.anatomical_structure Vagina Cervix Mucus biology.protein Cytokines Cattle Female Biomarkers Acute-Phase Proteins Antimicrobial Cationic Peptides |
| Zdroj: | Veterinary Research Communications |
| ISSN: | 1573-7446 0165-7380 |
| DOI: | 10.1007/s11259-018-9734-0 |
| Popis: | Cervico-vaginal mucus (CVM), the product of epithelial cells lining the uterus, cervix and vagina, is secreted to facilitate uterine lubrication and microbial clearance. Predominantly composed of water and mucins, CVM also contains high levels of immuno-active proteins such as immunoglobulin A (IgA), lactoferrin and lysozyme which protect against infection by blocking adhesion and mediating microbial killing. The repertoire of cytokines, chemokines and antimicrobial peptides is predominantly generated by the secretions of endometrial epithelial cells into the uterine lumen and concentrated in the CVM. The quantity and relative proportions of these inflammatory biomarkers are affected by diverse factors including the estrus cycle and health status of the animal and therefore potentially provide important diagnostic and prognostic indicators. We propose that measuring molecular signatures in bovine CVM could be a useful approach to identifying and monitoring genital tract pathologies in beef and dairy cows. |
| Databáze: | OpenAIRE |
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